Lung adenocarcinoma (LADC) patients frequently harbor mutations in SMARCA4, a core component of this multisubunit complex.
However, the alteration of circulating Tph and CD138+ B in IgA nephropathy (IgAN) remains poorly understood.
Here, we present a detailed analysis of programmed B chromosome elimination in plants. Until now, the relationship between FOXA1 and the nasopharyngeal carcinoma (NPC) has not yet been reported.
We find that nucleosome patterni...Background:
Some studies have also implicated BET proteins as regulators of cell identity and differentiation through their interactions with lineage-specific factors. Propofol is an intravenous anesthetic agent that commonly induces significant neuroapoptosis. Methods:
Genome architecture had been notoriously difficult to elucidate, but the advent of the suite of chromatin conformation capture assays, notably Hi-...Background: The various approaches to developing new antimalarial agents rely on the understanding of the complex regulatory mechanisms of dynamic gene expression in the life-cycle of these malaria parasites.
Current high-throughput technologies for detecting PAIs, such as promoter capture Hi-C, are not scalable to large cohorts.
Using goatgrass Aegilops speltoides as a mod...Gene regulation by steroid hormones has been at the forefront in elucidating the intricacies of transcriptional regulation in eukaryotes ever since the discovery by Karlson and Clever that the insect steroid hormone ecdysone induces chromatin puffs in giant chromosomes. All rights reserved. Although repl...Background: Numerous literatures have demonstrated that circular RNAs (circRNAs) are involved in multiple types of tumors.
Although cells in these processes originate from isogenic cultures, heterogeneity induced by intrinsic and extrinsic influences is omnipresent.
This study aimed to explore the expression of BAF250a protein in breast c...Hepatic ischemia reperfusion (I/R) injury (HIRI) HIRI is a complex, multifactorial pathophysiological process and in liver surgery has been known to significantly affect disease prognosis, surgical success rates, and patient survival. However, the role of EphA5 in esophageal squamous cell carcinoma (ESCC) is not clear. Considering mesenchymal stem cell (MSC)-derived exosomes as promising natura...Background: Recent studies showed that e-CSF plays significant roles in embryonic brain development.
In this way, pathogens manipulate the host cell for their own survival. Here, we present a genetic screen coupled to pulse-chase labeling that allow us to identify proteins selectively involved in deposition of nascent CENP-A or in long-term transmission of chromatin-bound CENP-A. We found that TFs except for...Disruption of chromatin structure could enable early carcinogenesis by facilitating malignant transformation. The embryonic cerebrospinal fluid (e-CSF) contains various growth factors and morphogens. RT-qPCR was used to detect the expression of miR-125a-5p and GALNT7 in cervical cancer tissues and cell li...The oocyte cytoplasm can reprogram the somatic cell nucleus into a totipotent state, but with low efficiency.
Although the molecular details of zygotic genome activation (ZGA) are not well understood in most species, an emerging concept is that one or more pioneer transcription factors trigger...Despite histone H2A variants and acetylation of histones occurring in almost every eukaryotic organism, it has been difficult to establish direct functional links between canonical histones or H2A variant acetylation, deposition of H2A variants and transcription. Coupled with feature engineering a...Background:
The close relationship between neutrophils and the pathogenesis of endometriosis has been demonstrated.
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